"Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome". Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA (2003)."The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease". "Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase". Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE (2006)."Charcot-Marie-Tooth type 4B demyelinating neuropathy: deciphering the role of MTMR phosphatases". Previtali SC, Quattrini A, Bolino A (2007)."Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". ^ Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (Apr 2003).^ a b "Entrez Gene: MTMR2 myotubularin related protein 2"."Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". ^ Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (Dec 1998)."A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast". ^ Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Klauck SM, Poustka A, Dahl N (Jul 1996).^ a b "RecName: Full=Myotubularin-related protein 2 AltName: Full=Phosphatidylinositol-3,5-bisphosphate 3-phosphatase AltName: Full=Phosphatidylinositol-3-phosphate phosphatase".National Center for Biotechnology Information, U.S. MTMR2 has been shown to interact with SBF1. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. This gene is a member of the myotubularin family and encodes a putative tyrosine phosphatase. Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3-phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene. regulation of phosphatidylinositol dephosphorylation.phosphatidylinositol biosynthetic process.positive regulation of early endosome to late endosome transport.negative regulation of excitatory postsynaptic potential.negative regulation of receptor internalization.negative regulation of receptor catabolic process.
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